Endothelial cell differentiation function varies during telmisartan intervention for hypertension

doi:10.3969/j.issn.2095-4344.2015.07.024

Abstract

Abstract:

BACKGROUND: Studies have shown that in patients with essential hypertension endothelial cell damage is characterized as endothelin release imbalance. Telmisartan can recover the “dipper”-type blood pressure in hypertension patients, and has better antihypertensive effect than losartan and amlodipine, showing a stronger protective role.

OBJECTIVE: To investigate the effects of telmisartan on endothelial cell differentiation function and serum adiponectin in hypertension patients.

METHODS: Totally 160 patients with essential hypertension were equally divided into treatment group and control group according to lottery method. The control group was given Hyzaar treatment, while the treatment group received telmisartan treatment, one tablet per day that was taken orally in the morning. The treatment period was 4 weeks. Clinical efficacy, plasma adiponectin, plasma endothelin and nitric oxide levels were observed in the two groups. Correlation between plasma endothelin, plasma adiponectin and nitric oxide levels in patients with hypertension were analyzed.

RESULTS AND CONCLUSION: The effective rate was 92.5% in the treatment group and 75.0% in the control group, and there was a significant difference between the two groups (P < 0.05). After treatment, the plasma adiponectin and nitric oxide levels were significantly increased, and the plasma endothelin levels were decreased significantly in the two groups, with significant differences compared to pre-treatment (P < 0.05). Compared with the control group, the plasma endothelin level was significantly lower while the nitric oxide level was significantly higher in the treatment group after treatment (both P < 0.05). Pearson correlation test analysis showed that the plasma adiponectin levels were negatively correlated to the plasma endothelin levels (P < 0.05), but positively correlated to the plasma nitric oxide levels (P < 0.05). These findings indicate that telmisartan treatment can improve the prognosis and therapeutic effects on hypertension, and its role may be related to improve endothelial cell differentiation and increase serum adiponectin levels.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: Hypertension, Endothelial Cells, Adiponectin

CLC Number:

R318

Ma Jian, Zhang Yong, Cao Zheng. Endothelial cell differentiation function varies during telmisartan intervention for hypertension[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(7): 1117-1121.

Figures/Tables 4

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